College of Chemistry and Molecular Biosciences
I returned to Australia in 1993 to get up an ARC Postdoctoral Fellowship within the Australian Nationwide College (Canberra) from 1993-4. I joined the College of Queensland in 1994.
Research Passions and Collaborations
Protein Electrochemistry
This exploration consists of incorporating redox lively enzymes with electrochemical systems this kind of the enzyme capabilities natively although in communication using an electrode (instead of by using a normal electron transfer companion). We have been at the moment investigating a number of systems, most in the molybdenum enzyme family members that catalyse oxygen transfer reactions of both equally organic and natural and inorganic substrates.
Chelators for Fe Overload Problems
Fe overload can be described as probably lethal condition that impacts an important proportion belonging to the populace and its incidence is particularly problematic in building international locations. Its recent remedy is expensive and hugely invasive and compliance is bad. We’ve been doing work on getting orally lively medicine to treat Fe overload (collaboration with Prof. Richardson, Uni. of Sydney, Australia). Davis, Oxford College British isles).
Iron like a Target in Most cancers Treatment solution
Iron is really an crucial factor for nearly all varieties of life and some rapidly proliferating cancers which include leukemia and neuroblastoma possess a big need for Fe. Hence this substantial desire renders Fe as the attainable therapeutic focus on to sluggish cell cancer proliferation throught the administration of Fe chelators. We now have recognized plenty of chelators that exhibit seriously substantial exercise (and selectivity) towards cancer cells and we’ve been investigating their coordination chemistry intensively to higher have an understanding of the method of action of these possibilities medicine. (collaboration with Prof. Richardson, www.dataessantials.com/montblancpenscheap.html Uni. of Sydney, Australia).
Selected Publications
Bernhardt, P. V. Coordination chemistry and biology of chelators to the treatment of iron overload conditions. Dalton Trans. 2007, 3214-3220.
Rapson, T. D.; Kappler, www.sharereplicachristianlouboutin.com U.; Bernhardt, P. V. Direct catalytic electrochemistry of sulfite dehydrogenase: Mechanistic insights and contrasts with affiliated Mo enzymes. Biochim Biophys. Acta, Bioenerg. 2008, 1777, 1319-1325.
Chen, http://www.replicachristianlouboutinright.com K.-I.; McEwan, A. G.; Bernhardt, P. V. Mediated electrochemistry of dimethyl sulfoxide reductase from Rhodobacter capsulatus. J. Biol. Inorg. Chem. 2009, fourteen, 409-419.
Jansson, http://www.dataessantials.com/replicachristianlouboutin.html P. J.; Sharpe, P. C.; Bernhardt, P. V.; Richardson, D. R. Novel Thiosemicarbazones within the ApT and DpT Collection as well as their Copper Complexes: Identification of Pronounced Redox Exercise and Characterization in their Antitumor Action. J. Med. Chem. 2010, fifty three, www.replicachristianlouboutinright.com 5759-5769.
Bell, C. A.; Bernhardt, P. V.; Gahan, L. R.; Martinez, M.; Monteiro, christian louboutin shoes M. J.; Rodriguez, C.; Sharrad, C. A. Copper(II) Complexes of a Hexadentate Mixed-Donor N3S3 Macrobicyclic Cage: Facile Rearrangements and Interconversions. Chemistry-A European Journal 2010, 16, 3166-3175.
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